Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D

• Autores principales: Dana Avrahami (Autor), Yue J. Wang (Autor), Jonathan Schug (Autor), Eseye Feleke (Autor), Long Gao (Autor), Chengyang Liu (Autor), Ali Naji (Autor), Benjamin Glaser (Autor), Klaus H. Kaestner (Autor)
• Formato: Libro
• Publicado: Elsevier, 2020-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Objective: Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. Methods: We employed single-cell RNAseq to detail the maturation program of α- and β-cells dur...