Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D

• Main Authors: Dana Avrahami (Author), Yue J. Wang (Author), Jonathan Schug (Author), Eseye Feleke (Author), Long Gao (Author), Chengyang Liu (Author), Ali Naji (Author), Benjamin Glaser (Author), Klaus H. Kaestner (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. Methods: We employed single-cell RNAseq to detail the maturation program of α- and β-cells dur...