Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4

• Auteurs principaux: Jing Shi (Auteur), Yuanyuan Li (Auteur), Yi Zhang (Auteur), Jie Chen (Auteur), Jianqing Gao (Auteur), Tianyuan Zhang (Auteur), Xiaoguang Shang (Auteur), Xiangnan Zhang (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Inhibition of phosphodiesterase 2 and 4 (PDE2A and PDE4) increases the intracellular cAMP and/or cGMP levels, which may prevent Amyloid β 42 oligomers (Aβ) related cognitive impairment and dementias. Baicalein, one of natural flavones found in the root of Scutellaria baicalensis Georgi, has a wide r...