MicroRNA-221-3p Suppresses the Microglia Activation and Seizures by Inhibiting of HIF-1α in Valproic Acid-Resistant Epilepsy

• Autori principali: Meng Fu (Autore), Yiqing Zhu (Autore), Junqi Zhang (Autore), Wei Wu (Autore), Yunxia Sun (Autore), Xuemei Zhang (Autore), Jie Tao (Autore), Zhiping Li (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

One-third of patients with epilepsy suffer from drug-resistant epilepsy (DRE). Valproic acid (VPA) is a classic anticonvulsant drug, and its resistance is a crucial predictor of DRE, but the pathogenesis remain unknown. Most patients with VPA-resistant epilepsy appear distinct inflammatory response...