Pharmacovigilance of Herb-Drug Interactions: A Pharmacokinetic Study on the Combined Administration of Tripterygium Glycosides Tablets and Leflunomide Tablets in Rats by LC-MS/MS

• Main Authors: Hamza Boucetta (Author), Wei Wu (Author), Tao Hong (Author), Rui Cheng (Author), Jing Jiang (Author), Chengxi Liu (Author), Min Song (Author), Taijun Hang (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A popular and widely used combination therapy of leflunomide (LEF) and Tripterygium glycosides tablets (TGT_S) has become a valuable clinical tool in China for the treatment of rheumatoid arthritis. This regimen has not been evaluated either in terms of interaction or toxicity,...