Development of Dual Drug Loaded Nanosized Liposomal Formulation by A Reengineered Ethanolic Injection Method and Its Pre-Clinical Pharmacokinetic Studies

• Main Authors: Muhammad Sarfraz (Author), Attia Afzal (Author), Tan Yang (Author), Yongkang Gai (Author), Shahid Masood Raza (Author), Muhammad Waseem Khan (Author), Yao Cheng (Author), Xiang Ma (Author), Guangya Xiang (Author)
• Format: Book
• Published: MDPI AG, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oleanolic acid (OA), which is a natural pentacyclic terpenoid, has been identified for hepato-protective, nephron-protective and cardio-tonic properties. In contrast, doxorubicin (DOX) is a famous anti-cancer drug but its efficacy is a question mark because of its known cardio-toxicity. We developed...