Effect of Hypoxia on Siglec-7 and Siglec-9 Receptors and Sialoglycan Ligands and Impact of Their Targeting on NK Cell Cytotoxicity

• Main Authors: Husam Nawafleh (Author), Nagwa Zeinelabdin (Author), Michelle K. Greene (Author), Anitha Krishnan (Author), Linus Ho (Author), Mohamed Genead (Author), Derek Kunimoto (Author), Christopher J. Scott (Author), Michael Tolentino (Author), Salem Chouaib (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Objectives: Tumor microenvironmental hypoxia is an established hallmark of solid tumors. It significantly contributes to tumor aggressiveness and therapy resistance and has been reported to affect the balance of activating/inhibitory surface receptors' expression and activity on NK c...