Cefquinome-loaded microsphere formulations against Klebsiella pneumonia infection during experimental infections

• Main Authors: Shaoqi Qu (Author), Cunchun Dai (Author), Jiajia Zhu (Author), Li Zhao (Author), Yuwen Li (Author), Zhihui Hao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to prepare cefquinome-loaded polylactic acid microspheres and to evaluate their in vitro and in vivo characteristics and pharmacodynamics for the therapy of pneumonia in a rat model. Microspheres were prepared using a 0.7 mm two-fluid nozzle spray drier in one step resultin...