Targeting histone deacetylases for cancer therapy: Trends and challenges

• Main Authors: Tao Liang (Author), Fengli Wang (Author), Reham M. Elhassan (Author), Yongmei Cheng (Author), Xiaolei Tang (Author), Wengang Chen (Author), Hao Fang (Author), Xuben Hou (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and progression. As promising anticancer targets, HDACs have gained a great deal of research interests and two decades of effort has led to the approval of five HDAC inhibitors (HDACis). However, currently traditio...