The utility of Apc-mutant rats in modeling human colon cancer

• Main Authors: Amy A. Irving (Author), Kazuto Yoshimi (Author), Marcia L. Hart (Author), Taybor Parker (Author), Linda Clipson (Author), Madeline R. Ford (Author), Takashi Kuramoto (Author), William F. Dove (Author), James M. Amos-Landgraf (Author)
• Format: Book
• Published: The Company of Biologists, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prior to the advent of genetic engineering in the mouse, the rat was the model of choice for investigating the etiology of cancer. Now, recent advances in the manipulation of the rat genome, combined with a growing recognition of the physiological differences between mice and rats, have reignited in...