Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice

• Main Authors: Yoshiki HIRATA (Author), Yusuke KATSUKURA (Author), Yuka HENMI (Author), Ren OZAWA (Author), Sayaka SHIMAZAKI (Author), Akira KUROSAWA (Author), Yasushi TORII (Author), Hironori TAKAHASHI (Author), Hisataka IWATA (Author), Takehito KUWAYAMA (Author), Koumei SHIRASUNA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Advanced maternal age is a risk factor for female infertility, and placental dysfunction is considered one of the causes of pregnancy complications. We investigated the effects of advanced maternal aging on pregnancy outcomes and placental senescence. Female pregnant mice were separated into three g...