From AVATAR Mice to Patients: RC48-ADC Exerted Promising Efficacy in Advanced Gastric Cancer With HER2 Expression

• Main Authors: Zuhua Chen (Author), Jiajia Yuan (Author), Yingying Xu (Author), Cheng Zhang (Author), Zhongwu Li (Author), Jifang Gong (Author), Yanyan Li (Author), Lin Shen (Author), Jing Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RC48-ADC is a novel humanized antibody specific for human epidermal growth factor receptor 2 (HER2)in conjugation with a microtubule inhibitor via a cleavable linker. This study was to evaluate the antitumor activity and mechanism of RC48-ADC in gastric cancer (GC) and explore the population that ma...