Reverse and Forward Electron Flow-Induced H₂O₂ Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

• Main Authors: Gergő Horváth (Author), Gergely Sváb (Author), Tímea Komlódi (Author), Dora Ravasz (Author), Gergely Kacsó (Author), Judit Doczi (Author), Christos Chinopoulos (Author), Attila Ambrus (Author), László Tretter (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified in neurodegenerative diseases such as in Alzheimer's disease. The aim of the present study was to establish the role...