Reverse and Forward Electron Flow-Induced H₂O₂ Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

• Hlavní autoři: Gergő Horváth (Autor), Gergely Sváb (Autor), Tímea Komlódi (Autor), Dora Ravasz (Autor), Gergely Kacsó (Autor), Judit Doczi (Autor), Christos Chinopoulos (Autor), Attila Ambrus (Autor), László Tretter (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2022-07-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified in neurodegenerative diseases such as in Alzheimer's disease. The aim of the present study was to establish the role...