Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

• Main Authors: Xiaohuang Lin (Author), Jian Zhang (Author), Zekai Wu (Author), Yuan Shi (Author), Mengting Chen (Author), Maodong Li (Author), Hong Hu (Author), Kun Tian (Author), Xiaoqi Lv (Author), Chutao Li (Author), Yang Liu (Author), Xinyue Gao (Author), Qiaomei Yang (Author), Kunqi Chen (Author), An Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Mesaconitine (MA), a diester-diterpenoid alkaloid extracted from the medicinal herb Aconitum carmichaelii, is commonly used to treat various diseases. Previous studies have indicated the potent toxicity of aconitum despite its pharmacological activities, with limited understanding of its...