Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies

• Main Authors: Philippe-Henri Secretan (Author), Maxime Annereau (Author), Willy Kini-Matondo (Author), Bastien Prost (Author), Jade Prudhomme (Author), Lina Bournane (Author), Muriel Paul (Author), Najet Yagoubi (Author), Hassane Sadou-Yayé (Author), Bernard Do (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nirmatrelvir is an antiviral drug approved for the treatment of COVID-19. The available dosage form consists of tablets marketed under the brand name PAXLOVID^®. Although knowledge of nirmatrelvir's intrinsic stability may be useful for any potential development of other p...