A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke

• Main Authors: Chenglong Gao (Author), Yazhou Xu (Author), Zhuangzhuang Liang (Author), Yunjie Wang (Author), Qinghong Shang (Author), Shengbin Zhang (Author), Cunfang Wang (Author), Mingmin Ni (Author), Dalei Wu (Author), Zhangjian Huang (Author), Tao Pang (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blood-brain barrier (BBB) damage after ischemia significantly influences stroke outcome. Compound LFHP-1c was previously discovered with neuroprotective role in stroke model, but its mechanism of action on protection of BBB disruption after stroke remains unknown. Here, we show that LFHP-1c, as a di...