Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress.

• Main Authors: Deepak Kumar Deep (Author), Ruchi Singh (Author), Vasundhra Bhandari (Author), Aditya Verma (Author), Vanila Sharma (Author), Saima Wajid (Author), Shyam Sundar (Author), V Ramesh (Author), Jean Claude Dujardin (Author), Poonam Salotra (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in its efficacy with a high rate of relapse in VL as well as post kala-azar dermal leishmaniasis (PKDL). We investi...