Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [¹¹C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

• Main Authors: Louise Breuil (Author), Nora Ziani (Author), Sarah Leterrier (Author), Gaëlle Hugon (Author), Fabien Caillé (Author), Viviane Bouilleret (Author), Charles Truillet (Author), Maud Goislard (Author), Myriam El Biali (Author), Martin Bauer (Author), Oliver Langer (Author), Sébastien Goutal (Author), Nicolas Tournier (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

[¹¹C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may impact the plasma and brain...