Pharmacophore modeling and virtual screening for the discovery of new fatty acid amide hydrolase inhibitors

• मुख्य लेखकों: Dong-sheng Zhao (लेखक), Hai-yan Wang (लेखक), Zhi-hui Lian (लेखक), Da-xiong Han (लेखक), Xin Jin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2011-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A predictive pharmacophore model has been generated from a series of diverse fatty acid amide hydrolase (FAAH) inhibitors and the optimal pharmacophore model applied in virtual screening. The pharmacophore model was based on a training set of 21 compounds carefully selected from the published litera...