Targeting Protein Kinase CK2: Evaluating CX-4945 Potential for GL261 Glioblastoma Therapy in Immunocompetent Mice

• Main Authors: Laura Ferrer-Font (Author), Lucia Villamañan (Author), Nuria Arias-Ramos (Author), Jordi Vilardell (Author), Maria Plana (Author), Maria Ruzzene (Author), Lorenzo A. Pinna (Author), Emilio Itarte (Author), Carles Arús (Author), Ana Paula Candiota (Author)
• Format: Book
• Published: MDPI AG, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but resistance always ensues. Protein kinase CK2 (CK2) contributes to tumour development and proliferation in cancer, and it is overexpress...