Interactions between Angiotensin Type-1 Antagonists, Statins, and ROCK Inhibitors in a Rat Model of L-DOPA-Induced Dyskinesia

• Glavni autori: Andrea Lopez-Lopez (Autor), Rita Valenzuela (Autor), Ana Isabel Rodriguez-Perez (Autor), María J. Guerra (Autor), Jose Luis Labandeira-Garcia (Autor), Ana Muñoz (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2023-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Statins have been proposed for L-DOPA-induced dyskinesia (LID) treatment. Statin anti-dyskinetic effects were related to the inhibition of the Ras-ERK pathway. However, the mechanisms responsible for the anti-LID effect are unclear. Changes in cholesterol homeostasis and oxidative stress- and inflam...