A Data-Driven Reference Standard for Adverse Drug Reaction (RS-ADR) Signal Assessment: Development and Validation

• Main Authors: Suehyun Lee (Author), Jeong Hoon Lee (Author), Grace Juyun Kim (Author), Jong-Yeup Kim (Author), Hyunah Shin (Author), Inseok Ko (Author), Seon Choe (Author), Ju Han Kim (Author)
• Format: Book
• Published: JMIR Publications, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundPharmacovigilance using real-world data (RWD), such as multicenter electronic health records (EHRs), yields massively parallel adverse drug reaction (ADR) signals. However, proper validation of computationally detected ADR signals is not possible due to the lack of a reference standard for...