Fabrication, In Vitro and In Vivo Evaluation of Non-Ordered Mesoporous Silica-Based Ternary Solid Dispersions for Enhanced Solubility of Flurbiprofen

• Main Authors: Muhammad Usman Munir (Author), Mahnoor Ikraam (Author), Muhammad Nadeem (Author), Syed Haroon Khalid (Author), Sajid Asghar (Author), Ikrima Khalid (Author), Muhammad Irfan (Author), Nayyer Islam (Author), Nyla Ajaz (Author), Ikram Ullah Khan (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to improve the solubility and prevent the ulcerogenic effect of flurbiprofen. Initially, binary and ternary solid dispersions (BSDs and TSDs) of flurbiprofen were prepared by using non-ordered mesoporous silica and gelucire. After preformulation testing (solubility, flow pr...