No evidence of neuronal damage as measured by neurofilament light chain in a HIV cure study utilising a kick-and-kill approach

• Main Authors: Jasmini Alagaratnam (Author), Wolfgang Stöhr (Author), Jamie Toombs (Author), Amanda Heslegrave (Author), Henrik Zetterberg (Author), Magnus Gisslén (Author), Sarah Pett (Author), Mark Nelson (Author), Amanda Clarke (Author), Nneka Nwokolo (Author), Margaret A. Johnson (Author), Maryam Khan (Author), Tomas Hanke (Author), Jakub Kopycinski (Author), Lucy Dorrell (Author), Julie Fox (Author), Sabine Kinloch (Author), Jonathan Underwood (Author), Matthew Pace (Author), John Frater (Author), Alan Winston (Author), Sarah Fidler (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: HIV-remission strategies including kick-and-kill could induce viral transcription and immune-activation in the central nervous system, potentially causing neuronal injury. We investigated the impact of kick-and-kill on plasma neurofilament light (NfL), a marker of neuro-axonal injury, in...