Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

• Main Authors: Aneesh V. Karkhanis (Author), Gopalakrishnan Venkatesan (Author), Ryuichi Kambayashi (Author), Jacqueline Wen Hui Leow (Author), Marcus Qingrui Han (Author), Hiroko Izumi-Nakaseko (Author), Ai Goto (Author), Jeremy Kah Sheng Pang (Author), Boon Seng Soh (Author), Pipin Kojodjojo (Author), Atsushi Sugiyama (Author), Eric Chun Yong Chan (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug prescribed for treatment of atrial fibrillation (AF) induces cardiac adverse effects (AEs) with poorly understood mechanisms. We previously demonstr...