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Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug prescribed for treatment of atrial fibrillation (AF) induces cardiac adverse effects (AEs) with poorly understood mechanisms. We previously demonstr...

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Bibliographic Details
Main Authors:	Aneesh V. Karkhanis (Author), Gopalakrishnan Venkatesan (Author), Ryuichi Kambayashi (Author), Jacqueline Wen Hui Leow (Author), Marcus Qingrui Han (Author), Hiroko Izumi-Nakaseko (Author), Ai Goto (Author), Jeremy Kah Sheng Pang (Author), Boon Seng Soh (Author), Pipin Kojodjojo (Author), Atsushi Sugiyama (Author), Eric Chun Yong Chan (Author)
Format:	Book
Published:	Elsevier, 2022-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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