Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOA...

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Main Authors: Suparat Khamdang (Author), Michio Takeda (Author), Minoru Shimoda (Author), Rie Noshiro (Author), Shinichi Narikawa (Author), Xiu-Lin Huang (Author), Atsushi Enomoto (Author), Pawinee Piyachaturawat (Author), Hitoshi Endou (Author)
Format: Book
Published: Elsevier, 2004-01-01T00:00:00Z.
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