Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

• Príomhchruthaitheoirí: Suparat Khamdang (Údar), Michio Takeda (Údar), Minoru Shimoda (Údar), Rie Noshiro (Údar), Shinichi Narikawa (Údar), Xiu-Lin Huang (Údar), Atsushi Enomoto (Údar), Pawinee Piyachaturawat (Údar), Hitoshi Endou (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Elsevier, 2004-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOA...