Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation

• Main Authors: Harrison T. Muturi (Author), Hilda E. Ghadieh (Author), Suman Asalla (Author), Sumona G. Lester (Author), Getachew D. Belew (Author), Sobia Zaidi (Author), Raziyeh Abdolahipour (Author), Abhishek P. Shrestha (Author), Agnes O. Portuphy (Author), Hannah L. Stankus (Author), Raghd Abu Helal (Author), Stefaan Verhulst (Author), Sergio Duarte (Author), Ali Zarrinpar (Author), Leo A. van Grunsven (Author), Scott L. Friedman (Author), Robert F. Schwabe (Author), Terry D. Hinds, Jr (Author), Sivarajan Kumarasamy (Author), Sonia M. Najjar (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients with metabolic dysfunction-associated steatohepatitis (MASH). Global and hepatocyte-specific deletions of Ceacam1 impair insulin clearance to cause hepatic insulin resistance and steatosis. They also cau...