1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

• Главные авторы: Ondrej Benek (Автор), Lukas Hroch (Автор), Laura Aitken (Автор), Frank Gunn-Moore (Автор), Lucie Vinklarova (Автор), Kamil Kuca (Автор), Daniel I. Perez (Автор), Concepcion Perez (Автор), Ana Martinez (Автор), Zdenek Fisar (Автор), Kamil Musilek (Автор)
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• Опубликовано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предметы: article
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Several neurodegenerative disorders including Alzheimer's disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies. Recently, novel class of CK1-specific inhibitors with N...