Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidney

• Main Authors: Ryuta Asaumi (Author), Ken‐ichi Nunoya (Author), Yoshiyuki Yamaura (Author), Kunal S. Taskar (Author), Yuichi Sugiyama (Author)
• Format: Book
• Published: Wiley, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract P‐glycoprotein (P‐gp) is an efflux transporter that plays an important role in the pharmacokinetics of its substrate, and P‐gp activities can be altered by induction and inhibition effects of rifampicin. This study aimed to establish a physiologically based pharmacokinetic (PBPK) model of r...