Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa

• Asıl Yazarlar: Michael A. Robichaux (Yazar), Vy Nguyen (Yazar), Fung Chan (Yazar), Lavanya Kailasam (Yazar), Feng He (Yazar), John H. Wilson (Yazar), Theodore G. Wensel (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2022-05-01T00:00:00Z.
• Konular: article
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The P23H mutation in rhodopsin (Rho), the rod visual pigment, is the most common allele associated with autosomal-dominant retinitis pigmentosa (adRP). The fate of misfolded mutant Rho in rod photoreceptors has yet to be elucidated. We generated a new mouse model, in which the P23H-Rho mutant allele...