SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice

Abstract.: To determine if endogenously generated sphingosine-1-phosphate (S1P) is involved in the development of allergic bronchial asthma, the effects of systemic treatments with SKI-II, a specific inhibitor of sphingosine kinase, on antigen-induced bronchial smooth muscle (BSM) hyperresponsivenes...

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Main Authors: Yoshihiko Chiba (Author), Hiroki Takeuchi (Author), Hiroyasu Sakai (Author), Miwa Misawa (Author)
Format: Book
Published: Elsevier, 2010-01-01T00:00:00Z.
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