Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

• Main Authors: Brian D. Guth (Author), Michael Engwall (Author), Sandy Eldridge (Author), C. Michael Foley (Author), Liang Guo (Author), Gary Gintant (Author), John Koerner (Author), Stanley T. Parish (Author), Jennifer B. Pierson (Author), Alexandre J. S. Ribeiro (Author), Tanja Zabka (Author), Khuram W. Chaudhary (Author), Yasunari Kanda (Author), Brian Berridge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclinical drug development. Detection of such effects ea...