The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia

• Main Authors: Nadia Danilova (Author), Elena Bibikova (Author), Todd M. Covey (Author), David Nathanson (Author), Elizabeth Dimitrova (Author), Yoan Konto (Author), Anne Lindgren (Author), Bertil Glader (Author), Caius G. Radu (Author), Kathleen M. Sakamoto (Author), Shuo Lin (Author)
• Format: Book
• Published: The Company of Biologists, 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribosomal biogenesis involves the processing of pre-ribosomal RNA. A deficiency of some ribosomal proteins (RPs) impairs processing and causes Diamond Blackfan anemia (DBA), which is associated with anemia, congenital malformations and cancer. p53 mediates many features of DBA, but the mechanism of...