SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models

• Main Authors: Martina Marinello (Author), Andreas Werner (Author), Mariagiovanna Giannone (Author), Khadija Tahiri (Author), Sandro Alves (Author), Christelle Tesson (Author), Wilfred den Dunnen (Author), Jacob-S. Seeler (Author), Alexis Brice (Author), Annie Sittler (Author)
• Format: Book
• Published: The Company of Biologists, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar ataxia type 7 (SCA7) is the intranuclear accumulation of mutant, misfolded ataxin-7 (polyQ-ATXN7). Here, we show that endogen...