Digoxin, an Overlooked Agonist of RORγ/RORγT

• Main Authors: Kaja Karaś (Author), Anna Sałkowska (Author), Marta Sobalska-Kwapis (Author), Aurelia Walczak-Drzewiecka (Author), Dominik Strapagiel (Author), Jarosław Dastych (Author), Rafał A. Bachorz (Author), Marcin Ratajewski (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...