Trimetazidine Modulates Mitochondrial Redox Status and Disrupted Glutamate Homeostasis in a Rat Model of Epilepsy

• Ngā kaituhi matua: Muhammad Y. Al-Shorbagy (Author), Walaa Wadie (Author), Dalia M. El-Tanbouly (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Mitochondrial oxidative status exerts an important role in modulating glia-neuron interplay during epileptogenesis. Trimetazidine (TMZ), a well-known anti-ischemic drug, has shown promising potential against a wide range of neurodegenerative disorders including epilepsy. Nevertheless, the exact mech...