Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae.

• Main Authors: Kidist Bobosha (Author), Elisa M Tjon Kon Fat (Author), Susan J F van den Eeden (Author), Yonas Bekele (Author), Jolien J van der Ploeg-van Schip (Author), Claudia J de Dood (Author), Karin Dijkman (Author), Kees L M C Franken (Author), Louis Wilson (Author), Abraham Aseffa (Author), John S Spencer (Author), Tom H M Ottenhoff (Author), Paul L A M Corstjens (Author), Annemieke Geluk (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Field-applicable tests detecting asymptomatic Mycobacterium leprae (M. leprae) infection or predicting progression to leprosy, are urgently required. Since the outcome of M. leprae infection is determined by cellular- and humoral immunity, we aim to develop diagnostic tests detecting pro-...