Cigarette Smoke Exposure Inhibits Bacterial Killing via TFEB-Mediated Autophagy Impairment and Resulting Phagocytosis Defect

• Главные авторы: Garrett Pehote (Автор), Manish Bodas (Автор), Kathryn Brucia (Автор), Neeraj Vij (Автор)
• Формат: ‌
• Опубликовано: Hindawi Limited, 2017-01-01T00:00:00Z.
• Предметы: article
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Introduction. Cigarette smoke (CS) exposure is the leading risk factor for COPD-emphysema pathogenesis. A common characteristic of COPD is impaired phagocytosis that causes frequent exacerbations in patients leading to increased morbidity. However, the underlying mechanism is unclear. Hence, we inve...