Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis

• Main Authors: Weilong Zhong (Author), Xia Wu (Author), Wei Zhang (Author), Jie Zhang (Author), Xiaofan Chen (Author), Shihong Chen (Author), Haiyan Huang (Author), Yong Yang (Author), Bo Yu (Author), Xia Dou (Author)
• Format: Book
• Published: Medical Journals Sweden, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in chronic itch and inflammation. This study investiga...