Dynamic crosslinked polymeric nano-prodrugs for highly selective synergistic chemotherapy

• Main Authors: Shi Wang (Author), Yining Song (Author), Jingge Ma (Author), Xinyang Chen (Author), Yuanhui Guan (Author), Hui Peng (Author), Guoqing Yan (Author), Rupei Tang (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To achieve highly selective synergistic chemotherapy attractive for clinical translation, the precise polymeric nano-prodrugs (PPD-NPs) were successfully constructed via the facile crosslinking reaction between pH-sensitive poly(ortho ester)s and reduction-sensitive small molecule synergistic prodru...