Inhibition of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and atherosclerotic lesion development in ApoE−/− mice

• Main Authors: Bao-Li Zhang (Author), Peng Yu (Author), En-Yong Su (Author), Chun-Yu Zhang (Author), Shi-Yao Xie (Author), Xue Yang (Author), Yun-Zeng Zou (Author), Ming Liu (Author), Hong Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyroptosis is a form of pro-inflammatory cell death that can be mediated by gasdermin D (GSDMD) activation induced by inflammatory caspases such as caspase-1. Emerging evidence suggests that targeting GSDMD activation or pyroptosis may facilitate the reduction of vascular inflammation and atheroscle...