Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties

• Main Authors: Roberta Rocca (Author), Francesca Scionti (Author), Matteo Nadai (Author), Federica Moraca (Author), Annalisa Maruca (Author), Giosuè Costa (Author), Raffaella Catalano (Author), Giada Juli (Author), Maria Teresa Di Martino (Author), Francesco Ortuso (Author), Stefano Alcaro (Author), Pierosandro Tagliaferri (Author), Pierfrancesco Tassone (Author), Sara N. Richter (Author), Anna Artese (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to be involved in telomere length and tran...