Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential

• Main Authors: Lu Gan (Author), Yanan Yang (Author), Qian Li (Author), Yi Feng (Author), Tianshu Liu (Author), Weijian Guo (Author)
• Format: Knjiga
• Izdano: BMC, 2018-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 also functions both as a transcriptional suppressor and a transcript...