Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling

• Main Authors: Fan Wu (Author), Yan Zhao (Author), Qingqing Shao (Author), Ke Fang (Author), Ruolan Dong (Author), Shujun Jiang (Author), Fuer Lu (Author), Jinlong Luo (Author), Guang Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Natural product, osthole, has been proven to have a protective effect on organ fibrosis, including renal fibrosis. All of these studies are mainly focused on the regulation of TGF-β/Smad signaling pathway. However, due to the pleiotropic roles of TGF-β/Smad signaling, direct TGF-β-target...