A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development

• Principais autores: Sarah Kim (Autor), Gezim Lahu (Autor), Majid Vakilynejad (Autor), Theodoros G. Soldatos (Autor), David B. Jackson (Autor), Lawrence J. Lesko (Autor), Mirjam N. Trame (Autor)
• Formato: Livro
• Publicado em: Wiley, 2022-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Adverse drug reactions (ADRs) of targeted therapy drugs (TTDs) are frequently unexpected and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of‐concept study, we explored how molecular causation involved in trastuzumab‐induced cardiotoxicity changes when tr...