Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia

• Main Authors: Mengistu Lemecha (Author), Jaya Prakash Chalise (Author), Yuki Takamuku (Author), Guoxiang Zhang (Author), Takahiro Yamakawa (Author), Garrett Larson (Author), Keiichi Itakura (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adipose tissue is the largest endocrine organ. When activated by cancer cells, adipocytes secrete adipocytokines and release fatty acids, which are then transferred to cancer cells and used for structural and biochemical support. How this metabolic symbiosis between cancer cells and adipo...