Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor

• Main Authors: Yuhong Cao (Author), Jiahao Fang (Author), Yiwei Shi (Author), Hui Wang (Author), Xiaofei Chen (Author), Yue Liu (Author), Zhenyu Zhu (Author), Yan Cao (Author), Zhanying Hong (Author), Yifeng Chai (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp) highly expressed in cancer cells can lead to multidrug resistance (MDR) and the combination of anti-cancer drugs with P-gp inhibitor has been a promising strategy to reverse MDR in cancer treatment. In this study, we established a label-free and detergent-free system combining...