Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor

• Главные авторы: Yuhong Cao (Автор), Jiahao Fang (Автор), Yiwei Shi (Автор), Hui Wang (Автор), Xiaofei Chen (Автор), Yue Liu (Автор), Zhenyu Zhu (Автор), Yan Cao (Автор), Zhanying Hong (Автор), Yifeng Chai (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2022-07-01T00:00:00Z.
• Предметы: article
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P-glycoprotein (P-gp) highly expressed in cancer cells can lead to multidrug resistance (MDR) and the combination of anti-cancer drugs with P-gp inhibitor has been a promising strategy to reverse MDR in cancer treatment. In this study, we established a label-free and detergent-free system combining...