Antioxidative Sirt1 and the Keap1-Nrf2 Signaling Pathway Impair Inflammation and Positively Regulate Autophagy in Murine Mammary Epithelial Cells or Mammary Glands Infected with <i>Streptococcus uberis</i>

• Main Authors: Sohrab Khan (Author), Tian Wang (Author), Eduardo R. Cobo (Author), Bingchun Liang (Author), Muhammad Asfandyar Khan (Author), Maolin Xu (Author), Weijie Qu (Author), Jian Gao (Author), Herman W. Barkema (Author), John P. Kastelic (Author), Gang Liu (Author), Bo Han (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Streptococcus uberis</i> mastitis in cattle infects mammary epithelial cells. Although oxidative responses often remove intracellular microbes, <i>S. uberis</i> survives, but the mechanisms are not well understood. Herein, we aimed to elucidate antioxidative mechanisms dur...