Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro-in vivo extrapolation

• Hlavní autoři: Engi Abdelhady Algharably (Autor), Emma Di Consiglio (Autor), Emanuela Testai (Autor), Francesca Pistollato (Autor), Anna Bal-Price (Autor), Abdulkarim Najjar (Autor), Reinhold Kreutz (Autor), Ursula Gundert-Remy (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied quantitative in vitro-in vivo extrapolation (QIVIVE) based on in vitro concentration and non-choline ester...