Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro-in vivo extrapolation

• Main Authors: Engi Abdelhady Algharably (Author), Emma Di Consiglio (Author), Emanuela Testai (Author), Francesca Pistollato (Author), Anna Bal-Price (Author), Abdulkarim Najjar (Author), Reinhold Kreutz (Author), Ursula Gundert-Remy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied quantitative in vitro-in vivo extrapolation (QIVIVE) based on in vitro concentration and non-choline ester...